Gene information
Official symbol IL18
Official full name interleukin 18
Gene type protein-coding gene
Chromosome11q23.1
Alias symbolIGIF; IL1F4; IL-1g; IL-18
Gene familyInterleukins
Resources
Entrez Gene 3606
HGNC HGNC:5986
Ensembl ENSG00000150782
Vega OTTHUMG00000167006
UCSC uc001pnb.2
GO terms: 167 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001906 cell killing GO Biological Processes -7.45870005 11 More
GO:0001909 leukocyte mediated cytotoxicity GO Biological Processes -5.30042050 7 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002228 natural killer cell mediated immunity GO Biological Processes -2.04281609 3 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002274 myeloid leukocyte activation GO Biological Processes -20.6988408 25 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002702 positive regulation of production of molecular mediator of immune response GO Biological Processes -12.4206918 17 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002708 positive regulation of lymphocyte mediated immunity GO Biological Processes -8.31079168 13 More
GO:0002709 regulation of T cell mediated immunity GO Biological Processes -8.74858930 12 More
GO:0002711 positive regulation of T cell mediated immunity GO Biological Processes -6.00483593 8 More
GO:0002718 regulation of cytokine production involved in immune response GO Biological Processes -15.9157324 18 More
GO:0002720 positive regulation of cytokine production involved in immune response GO Biological Processes -8.11676834 10 More
GO:0002724 regulation of T cell cytokine production GO Biological Processes -9.29772341 9 More
GO:0002726 positive regulation of T cell cytokine production GO Biological Processes -6.29956701 6 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002825 regulation of T-helper 1 type immune response GO Biological Processes -5.99805120 6 More
GO:0002827 positive regulation of T-helper 1 type immune response GO Biological Processes -4.28303352 4 More
GO:0002828 regulation of type 2 immune response GO Biological Processes -8.52846045 8 More
GO:0002830 positive regulation of type 2 immune response GO Biological Processes -7.53000143 6 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010744 positive regulation of macrophage derived foam cell differentiation GO Biological Processes -12.0744578 9 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030104 water homeostasis GO Biological Processes -1.35926419 3 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031663 lipopolysaccharide-mediated signaling pathway GO Biological Processes -14.0408172 12 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032148 activation of protein kinase B activity GO Biological Processes -8.71311579 12 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032656 regulation of interleukin-13 production GO Biological Processes -4.09160195 4 More
GO:0032660 regulation of interleukin-17 production GO Biological Processes -6.79373102 8 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032729 positive regulation of interferon-gamma production GO Biological Processes -7.58110530 10 More
GO:0032736 positive regulation of interleukin-13 production GO Biological Processes -4.89406977 4 More
GO:0032740 positive regulation of interleukin-17 production GO Biological Processes -4.70812216 5 More
GO:0032814 regulation of natural killer cell activation GO Biological Processes -6.02130395 7 More
GO:0032817 regulation of natural killer cell proliferation GO Biological Processes -3.34912948 3 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0036230 granulocyte activation GO Biological Processes -5.56986570 6 More
GO:0042088 T-helper 1 type immune response GO Biological Processes -3.92689699 4 More
GO:0042092 type 2 immune response GO Biological Processes -5.63167427 4 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042119 neutrophil activation GO Biological Processes -4.98581398 8 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042267 natural killer cell mediated cytotoxicity GO Biological Processes -2.11862029 3 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.90313372 12 More
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO Biological Processes -5.73056952 6 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043588 skin development GO Biological Processes -3.97728448 25 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045580 regulation of T cell differentiation GO Biological Processes -7.18541630 25 More
GO:0045582 positive regulation of T cell differentiation GO Biological Processes -5.99210992 10 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045619 regulation of lymphocyte differentiation GO Biological Processes -8.78322888 17 More
GO:0045621 positive regulation of lymphocyte differentiation GO Biological Processes -6.96534841 12 More
GO:0045622 regulation of T-helper cell differentiation GO Biological Processes -5.35296451 10 More
GO:0045624 positive regulation of T-helper cell differentiation GO Biological Processes -3.92081595 4 More
GO:0045628 regulation of T-helper 2 cell differentiation GO Biological Processes -5.22169943 4 More
GO:0045630 positive regulation of T-helper 2 cell differentiation GO Biological Processes -6.17980212 4 More
GO:0045661 regulation of myoblast differentiation GO Biological Processes -4.24103271 7 More
GO:0045662 negative regulation of myoblast differentiation GO Biological Processes -6.15988440 6 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0046006 regulation of activated T cell proliferation GO Biological Processes -6.86981007 8 More
GO:0046634 regulation of alpha-beta T cell activation GO Biological Processes -7.20313216 11 More
GO:0046635 positive regulation of alpha-beta T cell activation GO Biological Processes -5.84288222 8 More
GO:0046637 regulation of alpha-beta T cell differentiation GO Biological Processes -6.05306731 14 More
GO:0046638 positive regulation of alpha-beta T cell differentiation GO Biological Processes -5.69888611 7 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050891 multicellular organismal water homeostasis GO Biological Processes -1.44503545 3 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055090 acylglycerol homeostasis GO Biological Processes -12.4730141 17 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0070328 triglyceride homeostasis GO Biological Processes -12.4730141 17 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0120161 regulation of cold-induced thermogenesis GO Biological Processes -19.1025541 38 More
GO:0120162 positive regulation of cold-induced thermogenesis GO Biological Processes -19.5569802 32 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:0150078 positive regulation of neuroinflammatory response GO Biological Processes -8.75781093 7 More
GO:1901224 positive regulation of NIK/NF-kappaB signaling GO Biological Processes -6.64954322 9 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation GO Biological Processes -5.84288222 8 More
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation GO Biological Processes -5.27280402 6 More
KEGG pathways: 16 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04621 NOD-like receptor signaling pathway KEGG Pathway -7.63493695 15 More
hsa04623 Cytosolic DNA-sensing pathway KEGG Pathway -5.78243801 8 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05131 Shigellosis KEGG Pathway -5.26807538 14 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05135 Yersinia infection KEGG Pathway -7.02427022 12 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05321 Inflammatory bowel disease KEGG Pathway -16.3800424 16 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
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Related drugs: 7 records
Related studies: 18 records
Molecular factor Omics type Application Objective MI type Reference
NM_001562.4:c.[-656G>T;-119A>C;-9+3005A>G;-8-919G>A;-8-372C>G;361-221C>A] genomics myocardial infarction[diagnosis] myocardial infarction Bis JC et al. Atherosclerosis. 2008
NM_001562.4:c.[-656G>T;-105C>T;-8-1360A>G;91+488G>C;361-221C>A;*183A>G] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
interleukin-18 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Narins CR et al. Am J Cardiol. 2004
interleukin-18 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Youssef AA et al. Circ J. 2007
interleukin-18 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Youssef AA et al. Circ J. 2007
interleukin-18 proteomics good predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Gao Y et al. Int Heart J. 2010
interleukin-18 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Gao Y et al. Int Heart J. 2010
NM_001562.4:c.-9+3005A>G genomics myocardial infarction[diagnosis] myocardial infarction Bis JC et al. Atherosclerosis. 2008
NM_001562.4:c.-607C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Pei F et al. Clin Chem Lab Med. 2009
NM_001562.4:c.*183A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
NM_001562.4:c.-105C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
NM_001562.4:c.361-221C>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
NM_001562.4:c.-656G>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
NM_001562.4:c.-8-1360A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
NM_001562.4:c.91+488G>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Koch W et al. Cytokine. 2011
NM_001562.4:c.*183A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Opstad TB et al. PLoS One. 2013
interleukin-18 proteomics coronary restenosis[prognosis (bad)] acute myocardial infarction Kawasaki D et al. Am J Cardiol. 2003
interleukin-18 proteomics coronary atherosclerosis[prognosis (bad)] old myocardial infarction Hulthe J et al. Atherosclerosis. 2006
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